Post Doctoral Associate-Kozai Lab

The University of Pittsburgh BIONIC lab is seeking a Postdoctoral Associate in the field of neural engineering, with a focus on advancing our understanding of neural interface technology. The successful candidate will contribute to cutting-edge research aimed at bridging the gap between neurophysiology and engineering. Responsibilities include conducting experiments, analyzing data, and collaborating with a multidisciplinary team to develop innovative solutions for neurological disorders. Candidates should have a strong background in neuroengineering, electrophysiology, or related fields, with experience in experimental design and data analysis. Excellent communication and teamwork skills are essential. This is an exciting opportunity to join a dynamic research environment at the forefront of neural engineering.

About the project: Our postdoctoral position focuses on unraveling the impact of oligodendrocytes on chronic recording and neuromodulation failure around implanted microelectrodes, addressing critical challenges in neural engineering, stroke, traumatic brain injury (TBI), multiple sclerosis (MS), Alzheimer’s Disease (AD), and neuroregeneration. Using cutting-edge in vivo imaging technology, we aim to reveal real-time structural, cellular, and molecular responses, advancing fundamental science and informing the improvement of neural interface technologies and the treatment of neurological disorders. Oligodendrocytes, often overlooked in chronic recording failure, are central to our investigation. Through meticulous examination, we seek to elucidate their role in negative tissue responses surrounding microelectrodes, leveraging transgenic indicators, electrode design modifications, pharmaceutical interventions, and gliomodulation technologies (including neurostimulation, optogenetics, DDREADS, and ultrasound) to modulate progenitor cells, enhance oligodendrocyte health, and improve neurotechnology performance over time. This multifaceted approach promises groundbreaking insights into the dynamic interaction between neural interfaces and the brain's cellular environment, paving the way for innovative interventions in neuroengineering and clinical neuroscience.

Desired Skills:

• Expertise in in vivo multiphoton microscopy, electrophysiology, or neuromodulation, especially in the visual cortex.

• Experience in electrochemistry, confocal microscopy, signal processing (ImageJ/Fiji and MATLAB), immunohistochemistry, and SEM are preferred.

• Knowledge of the neurobiology of brain injuries and neurodegeneration is advantageous. (esp. MS, AD, and stroke)

Qualifications:

• For Postdoctoral Candidates: Ph.D. in Biomedical Engineering, Neurobiology, Neuroscience, Molecular/Cellular Biology, Biochemistry, Chemistry, Electrical Engineering, Computer Science, Mechanical Engineering, Chemical Engineering, Physics, Optics, Material Science, or Mathematics.

• A strong research background in electrophysiology, two-photon microscopy, or neurobiology is desired.

Interested candidates should submit a statement on the alignment of the candidate’s research interest to the lab (https://www.bioniclab.org/) and relevant research experience, curriculum vitae, the names of three references, and date of availability.

The University of Pittsburgh is committed to championing all aspects of diversity, equity, inclusion, and accessibility within our community. This commitment is a fundamental value of the University and is crucial in helping us advance our mission, which includes attracting and retaining diverse workforces. We will continue to create and maintain an environment that allows individuals to discover, belong, contribute, and grow, while honoring the experiences, perspectives, and unique identities of all.

The University of Pittsburgh is an Affirmative Action/Equal Opportunity Employer and values equality of opportunity, human dignity and diversity. EOE, including disability/vets.